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Selected publications

Reguzova, A., et al., A Novel Orf Virus D1701-VrV-Based Dengue Virus (DENV) Vaccine Candidate Expressing HLA-Specific T Cell Epitopes: A Proof-of-Concept Study. Biomedicines, 2021. 9(12).

Lothert, K., et al., A scalable downstream process for the purification of the cell culture-derived Orf virus for human or veterinary applications. J Biotechnol, 2020. 323: p. 221-230.

Lothert, K., et al., Selection of chromatographic methods for the purification of cell culture-derived Orf virus for its application as a vaccine or viral vector. J Biotechnol, 2020. 323: p. 62-72.

Reguzova A, Ghosh M, Müller M, Rziha HJ, Amann R. Orf Virus-Based Vaccine Vector D1701-V Induces Strong CD8+ T Cell Response against the Transgene but Not against ORFV-Derived Epitopes. Vaccines (Basel). 2020;8(2):E295. Published 2020 Jun 10. doi:10.3390/vaccines8020295

Schneider M, Müller M, Yigitliler A, et al. An Orf Virus-based therapeutic vaccine for the treatment of papillomavirus-induced tumors [published online ahead of print, 2020 May 13]. J Virol. 2020;JVI.00398-20. doi:10.1128/JVI.00398-20

Rall I., Amann R., Malberg S., Herden C., Rubbenstroth D., Recombinant Modified Vaccinia Virus Ankara (MVA) Vaccines Efficiently Protect Cockatiels Against Parrot Bornavirus Infection and Proventricular Dilatation Disease. Viruses. 2019 Dec 6;11(12).

Rziha H.J., Büttner M., Müller M., Salomon F., Reguzova A., Laible D., Amann R. (2019). Genomic Characterization of Orf Virus Strain D1701-V (Parapoxvirus) and Development of Novel Sites for Multiple Transgene Expression. Viruses 11(2).

Hanns-Joachim Rziha, Jörg Rohde, and Ralf Amann. Generation and Selection of Orf Virus (ORFV) Recombinants Methods Mol. Biol. 2016,  p. 177-200. doi: 10.1007/978-1-4939-3008-1_12.(book chapter)

Rohde J, Amann R, Rziha HJ. New Orf Virus (Parapoxvirus) Recombinant Expressing H5 Hemagglutinin Protects Mice against H5N1 and H1N1 Influenza A Virus. PLoS One. 20;8(12):e83802; 2013. 

Amann R, Rohde J, Wulle U, Conlee D, Raue R, Martinon O, Rziha HJ. A new rabies vaccine based on a recombinant ORF virus (parapoxvirus) expressing the rabies virus glycoprotein. J Virol. 87(3):1618-30; 2013.

Rohde, J., Schirrmeier, H., Granzow, H. and H.-J. Rziha. A new recombinant Orf virus (ORFV, Parapoxvirus) protects rabbits against lethal infection with rabbit hemorrhagic disease virus (RHDV). Vaccine 29, 9256-9264; 2011.

van Rooij, E.M.A., Rijsewijk, F.A.M., Moonen-Leusen, H.W., Bianchi, A.T.J. and H.-J. Rziha. Comparison of different prime-boost regimes with DNA and recombinant Orf virus based vaccines expressing glycoprotein D of pseudorabies virus in pigs. Vaccine 28, 1808-1813; 2010.

Grabowska, A.K., Lipinska, A.D., Rohde, J., Szewczyk, B, Bienkowska-Szewczyk, K. and H.-J. Rziha. New baculovirus recombinants expressing Pseudorabies virus (PRV) glycoproteins protect mice against lethal challenge infection. Vaccine 27, 3584-3591; 2009.

Dory, D., T. Fischer, V. Beven, R. Cariolet, H.-J. Rziha and A. Jestin. Prime-boost immunization using DNA vaccine and recombinant Orf virus protects pigs against Pseudorabies virus (Herpes suid 1). Vaccine 24, 6256-6263; 2006.

Hausmann, J., A. Pagenstecher, K. Baur, H.-J. Rziha and P. Staeheli. CD8 T cells require gamma interferon to clear Borna disease virus from the brain and prevent immune system-mediated neuronal damage. J. Virol. 79, 13509-13518; 2005.

Henkel, M., Planz, O., Fischer, T., Stitz, L. and H.-J. Rziha. Prevention of virus persistence and protection against immunopathology after Borna disease virus infection of the brain by a novel Orf virus recombinant. J. Virol. 79, 314-325; 2005.

Fischer, T., O. Planz, L. Stitz and H.-J. Rziha. Novel recombinant Parapoxvirus vectors induce protective humoral and cellular immunity against lethal herpesvirus challenge infection in mice. J. Virol. 77, 9312-9323; 2003.

Rziha, H.-J., M. Henkel, R. Cottone, B. Bauer, U. Auge, F. Götz, E. Pfaff, Röttgen, M., Dehio, C. and M. Büttner. Generation of recombinant parapoxviruses: Non-essential genes suitable for insertion and expression of foreign genes. J. Biotechnol., 83, 137-145; 2000.

Meyer, M., C. Lanz, M. Clauss, A. Lepple-Wienhaus, J. Waltenberger, H.G. Augustin, M. Ziche, M. Büttner, H.-J. Rziha and C. Dehio. A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling by VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinase. EMBO J. 18, 363-374; 1999.