Innate immunity employs so-called pattern recognition receptors (PRRs) to detect a variety of different microbes, including bacteria, viruses and fungi, as well as sense endogenous danger. Upon engagement, PRRs initiate distinct intracellular signaling pathways via receptor-proximal adaptor molecules, and initiate subsequent effector responses, e.g. transcription factor-mediated gene transcription or caspase-mediated cleavage events.
As detailed under “Research projects” our scientific focus is on understanding PRR signaling pathways on the molecular and cellular level with particular emphasis on the determinants of ligand recognition, signal transduction events (and their regulation), as well as the influence of genetic variants in PRR on these processes. We seek to address these questions in cellular model systems but also in primary cells, discerning between normal and e.g. transformed cells to investigate the manifold roles of PRR in different relevant biological systems.
These research questions are addressed by a unique team consisting of several technicians, two post-docs and five PhD students. The lab is well funded and equipped with state-of-the-art equipment. You would find a friendly, well-connected and highly international environment, and a firm commitment to good scientific practice, good supervision and professional development. As we are always seeking to recruit additional excellent and enthusiastic researchers, we welcome applications with the usual documents.
Alexander N.R. Weber (PhD); Professor for Innate Immunity
University of Tübingen Interfaculty Institute for Cell Biology Department of Immunology Auf der Morgenstelle 15 Office 1.002 72076 Tübingen Germany