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Section Innate Immunity (Weber à see “Groups” page), Dept. of Immunology, Tübingen

Principles of Chitin Recognition and Signaling

Topic | The innate immune systems in plants and humans rely on the recognition of microbes through conserved molecular patterns by so-called pattern recognition receptors (PRRs). However, the human PRR for chitin, a medically relevant, abundant polysaccharide found in insects and fungi and in humans associated with multiple diseases, remains unknown. Using biochemical, immunological and cellular methodologies, our lab aims to dissect principles of chitin recognition in mammals by using a multi-faceted, collaborative, interdisciplinary and interfaculty approach to obtain insights into principles of pathogen recognition and innate immunity across lineages.

Suggested reading | Kawai & Akira. Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity. Immunity 2011. Lee, Da Silva, Lee, Hartl & Elias. Chitin regulation of immune responses: an old molecule with new roles. Curr Opin Immunol 2008.

Methods | Standard molecular biology (PCR, restriction digests, sub-cloning), reporter signaling assays, analyses in human primary immune cells (phospho-flow cytometry, intracellular cytokine stain), protein-protein and protein-ligand interaction assays, phospho-proteomics, protein expression and purification.

The team | In order to execute this project and complement our laboratory team we are seeking to recruit additional excellent and enthusiastic researchers, including one PhD student. You would be part of a dynamic research group with a solid track record, and located in an excellent scientific environment, the Department of Immunology located on the University and University Hospital campus of Tübingen. In our well-funded laboratory you would find a friendly, well-connected and international environment, and a firm commitment to good supervision and professional development. International applicants are very welcome and will be supported in participating in German courses. German skills are not a requirement for application as English will generally be used in the work environment.

Further information | Starts Spring 2018, Duration: 3 years, Remuneration: DFG-funded German TV-L E13 65% position. Application open à apply NOW!

Your profile | Masters degree or equivalent in biological sciences or medicine, and some research experience in molecular/cellular biology, microbiology/virology, protein biochemistry and/or immunology; high motivation to work independently and as part of a team; good command of the English language (written and spoken); both German and international applications encouraged.

Your application | Please send the following complete materials electronically to (@) Cover/motivation letter (max 1 A4), CV, transcripts/certificate of diploma and bachelor degree, support letter from at least 1 previous supervisor. Applications will be reviewed on an ongoing basis.