Prof. Dr. Stefan Stevanović



Publications 2013

Prof. Dr. Stefan Stevanović





Dannenmann SR, Hermanns T, Bransi A, Matter C, von Boehmer L, Stevanovic S, Schraml P, Moch H, Knuth A, van den Broek M (2013) Spontaneous peripheral T cell responses towards the tumor-associated antigen Cyclin D1 in patients with clear cell renal cell carcinoma. Cancer Immunology Research (in press)

Laske K, Shebzukhov YV, Grosse-Hovest L, Kupras DV, Khlgatian SV, Koroleva EP, Sazykin AY, Penkov DN, Belousov PV, Stevanovic S, Vass V, Walter S, Eisel D, Schmid-Horch BD, Nedospasov SA, Rammensee HG, Gouttefangeas C (2013) Alternative variants of the human hydin are novel cancer-associated antigens recognized by adaptive immunity. Cancer Immunology Research (in press)

Neumann A, Hörzer H, Hillen N, Klingel K, Schmid-Horch B, Bühring HJ, Rammensee HG, Aebert H, Stevanovic S (2013) Identification of HLA ligands and T-cell epitopes for immunotherapy of lung cancer. Cancer Immunol Immunother 62:1485-1497

Adamopoulou E, Tenzer S, Hillen N, Klug P, Rota IA, Tietz S, Gebhardt M, Stevanovic S, Schild H, Tolosa E, Melms A, Stoeckle C (2013) Exploring the MHC-peptide matrix of central tolerance in the human thymus. Nat Commun 4:2039

Mohme M, Hotz C, Stevanovic S, Binder T, Lee JH, Okoniewski M, Eiermann T, Sospedra M, Rammensee HG, Martin R (2013) HLA-DR15-derived self peptides are involved in altered homeostatic T cell proliferation in multiple sclerosis. Brain 136:1783-1798

Geyeregger R, Freimüller C, Stevanovic S, Stemberger J, Mester G, Dmytrus J, Lion T, Rammensee HG, Fischer G, Eiz-Vesper B, Lawitschka A, Matthes S, Fritsch G (2013) Short-term in-vitro expansion improves monitoring and allows affordable generation of virus-specific T-cells against several viruses for a broad clinical application. PlosOne 8:e59592

Beutler N, Hauka S, Niepel A, Kowalewski DJ, Uhlmann J, Ghanem E, Erkelenz S, Wiek C, Hanenberg H, Schaal H, Stevanovic S, Springer S, Momburg F, Hengel H, Halenius A (2013) A natural tapasin isoform lacking exon 3 modifies peptide loading complex function. Eur J Immunol 43:1459-1469

Sturm T, Leinders-Zufall T, Maček B, Walzer M, Jung S, Pömmerl B, Stevanovic S, Zufall F, Overath P, Rammensee HG (2013) Mouse urinary peptides provide a molecular basis for genotype discrimination by nasal sensory neurons. Nat Commun 4:1616

Kostadinova E, Dolashka P, Velkova L, Dolashki A, Stevanovic S, Voelter W (2013) Positions of the glycans in molluscan hemocyanin, determined by fluorescence spectroscopy. J Fluoresc 23:753-760

Schreiner J, Kretschmer D, Klenk J, Otto M, Bühring HJ, Stevanovic S, Wang JM, Beer-Hammer S, Peschel A, Autenrieth SE (2013) Staphylococcus aureus phenol-soluble modulin peptides modulate dendritic cell functions and increase in vitro priming of regulatory T cells. J Immunol 190:3417-3426

Vogel R, Al-Daccak R, Drews O, Alonzeau J, Mester G, Charron D, Stevanovic S, Mallet J (2013) Mass spectrometry reveals changes in MHC I antigen presentation after lentivector expression of a gene regulation system. Mol Ther Nucleic Acids 2:e75

Neidert MC, Schoor O, Trautwein C, Trautwein N, Christ L, Melms A, Honegger J, Rammensee HG, Herold-Mende C, Dietrich PY, Stevanovic S (2013) Natural HLA class I ligands from glioblastoma: Extending the options for immunotherapy. J Neurooncol 111:285-294

Steinl C, Essl M, Schreiber TD, Geiger K, Prokop L, Stevanovic S, Pötz O, Abele H, Wessels JT, Aicher WK, Klein G (2013) Release of matrix metalloproteinase 8 during physiological trafficking and induced mobilization of human hematopoietic stem cells. Stem Cells Dev 22:1307-1318

2013 (Review articles)

Bedke J, Gouttefangeas C, Singh-Jasuja H, Stevanovic S, Behnes CL, Stenzl A (2013) Targeted therapy in renal cell carcinoma: Moving from molecular agents to specific immunotherapy. World J Urol (in press)

Trautwein N, Stevanovic S (2013) Establishing MHC class I peptide motifs. Methods Mol Biol 960:159-168

Kowalewski D, Stevanovic S (2013) Biochemical large-scale identification of MHC class I ligands. Methods Mol Biol 960:145-157

Publications 2012


Pohla H, Buchner A, Stadlbauer B, Frankenberger B, Stevanovic S, Walter S, Frank R, Schwachula T, Olek S, Kopp J, Willimsky G, Stief CG, Hofstetter A, Pezzutto A, Blankenstein T, Oberneder R, Schendel DJ (2012) High immune response rates and decreased frequencies of regulatory T cells in metastatic renal cell carcinoma patients after tumor cell vaccination. Mol Med 18:1499-1508 

Icheva V, Kayser S, Wolff D, Tuve S, Kyzirakos C, Bethge W, Greil J, Albert MH, Schwinger W, Nathrath M, Schumm M, Stevanovic S, Handgretinger R, Lang P, Feuchtinger T (2012) Adoptive transfer of EBNA1-specific T cells as a treatment of Epstein-Barr-Virus reactivation and lymphoproliferative disorders following allogeneic stem cell transplantation. J Clin Oncol 31:39-48

Leibold J, Feucht J, Halder A, Stevanovic S, Kayser S, Handgretinger R, Feuchtinger T (2012) Induction of Thelper1-driven antiviral T-cell lines for adoptive immunotherapy is determined by differential expression of IFN-γ and T-cell activation markers. J Immunother 35:661-669

Walter S, Weinschenk T, Stenzl A, Zdrojowy R, Pluzanska A, Szczylik C, Staehler M, Brugger W, Dietrich PY, Mendrzyk R, Hilf N, Schoor O, Fritsche J , Mahr A, Maurer D, Vass V, Trautwein C, Lewandrowski P, Flohr C, Pohla H, Stanczak JJ, Bronte V, Mandruzzato S, Biedermann T, Pawelec G, Derhovanessian E, Yamagishi H, Miki T, Hongo F, Takaha N, Hirakawa K, Tanaka H, Stevanovic S, Frisch J, Mayer-Mokler A, Kirner A, Rammensee HG, Reinhardt C, Singh-Jasuja H (2012) Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival. Nat Med 18:1254-1261

Thommen DS, Schuster H, Keller M, Kapoor S, Weinzierl AO, Chennakesava CS, Wang X, Rohrer L, von Eckardstein A, Stevanovic S, Biedermann BC (2012) Two preferentially expressed proteins protect vascular endothelial cells from an attack by peptide-specific CTL. J Immunol 188:5283-5292

Dutoit V, Herold-Mende C, Hilf H, Schoor O, Beckhove P, Bucher J, Dorsch K, Flohr S, Fritsche J, Lewandrowski P, Lohr J, Rammensee HG, Stevanovic S, Vass, Trautwein C, Walter S, Walker P, Weinschenk T, Singh-Jasuja H, Dietrich PY (2012) Exploiting the glioblastoma peptidome to discover novel tumour-associated antigens for immunotherapy. Brain 135:1042-1054

Wölk B, Trautwein C, Büchele B, Kersting N, Blum HE, Rammensee HG, Cerny A, Stevanovic S, Moradpour D, Brass V (2012) Identification of Naturally Processed Hepatitis C Virus-Derived Major Histocompatibility Complex Class I Ligands. Plos One 7:e29286

Blume KE, Soeroes S, Keppeler H, Stevanovic S, Kretschmer D, Rautenberg M, Wesselborg S, Lauber K (2012) Cleavage of annexin A1 by ADAM10 during secondary necrosis generates a monocytic 'find-me' signal. J Immunol 188:135-145

Preuß B, Berg C, Dengjel J, Stevanovic S, Klein R (2012) Relevance of the inner mitochondrial membrane enzyme F1F0-ATPase as an autoantigen in autoimmune liver disorders. Liver Int 32:249-257

Widenmeyer M, Griesemann H, Stevanovic S, Feyerabend S, Klein R, Attig S, Hennenlotter J, Wernet D, Kuprash D, Sazykin A, Pascolo S, Stenzl A, Gouttefangeas C, Rammensee HG (2012) Promiscuous survivin peptide induces robust CD4+ T-cell responses in the majority of vaccinated cancer patients. Int J Cancer 131:140-149

Publications 2011 - 1991



Dolashka P, Moshtanska V, Borisova V, Dolashki A, Stevanovic S, Dimanov T, Voelter W (2011) Antimicrobial proline-rich peptides from the hemolymph of marine snail Rapana venosa. Peptides 32:1477-1483

Neumann F, Kubuschok B, Ertan K, Schormann C, Stevanovic S, Preuss KD, Schmidt W, Pfreundschuh M (2011) A peptide epitope derived from the cancer testis antigen HOM-MEL-40/SSX2 capable of inducing CD4+ and CD8+ T-cell as well as B-cell responses. Cancer Immunol Immunother 60:1333-1346

Seliger B, Dressler SP, Massa C, Recktenwald CV, Altenberend F, Bukur J, Marincola FM, Wang E, Stevanovic S, Lichtenfels R (2011) Identification and characterization of human leukocyte antigen class I ligands in renal cell carcinoma cells. Proteomics 11:2528-2541 

Stuehler C, Khanna N, Bozza S, Zelante T, Moretti S, Kruhm M, Lurati S, Conrad B, Worschech E,  Stevanovic S, Krappmann S, Einsele H, Latgé JP, Loeffler J, Romani L, Topp MS (2011) Cross-protective TH1 immunity against Aspergillus fumigatus and Candida albicans. Blood 117:5881-5891

Stickel JS, Stickel N, Hennenlotter J, Klingel K, Stenzl A, Rammensee HG, Stevanovic S (2011) Quantification of HLA class I molecules on renal cell carcinoma using Edman degradation. BMC Urol 11:1-11

Ndhlovu M, Preuß BE, Dengjel J, Stevanovic S, Weiner SM, Klein R (2011) Identification of alpha-tubulin as an autoantigen recognized by sera from patients with neuropsychiatric systemic lupus erythematosus. Brain Behav Immun 25:279-285

Widenmeyer M, Shebzukhov Y, Haen SP, Schmidt D, Clasen S, Boss A, Kuprash D, Nedospasov SA, Stenzl A, Aebert H, Wernet D, Stevanovic S, Pereira PL, Rammensee HG, Gouttefangeas C (2011) Analysis of tumor antigen-specific T cells and antibodies in cancer patients treated with radiofrequency ablation. Int J Cancer 128:2653-2662


Stanke J, Hoffmann C, Erben U, von Keyserling H, Stevanovic S, Cichon G, Schneider A, Kaufmann AM (2010) A flow cytometry-based assay to assess minute frequencies of CD8+ T cells by their cytolytic function. J Immunol Methods 360:56-65

Staudt ND, Aicher WK, Kalbacher H, Stevanovic S, Carmona AK, Bogyo M, Klein G (2010) Cathepsin X is secreted by human osteoblasts, digests CXCL-12 and impairs adhesion of hematopoietic stem and progenitor cells to osteoblasts. Haematologica 95:1452-1460

Velkova L, Dimitrov I, Schwarz H, Stevanovic S, Voelter W, Salvato B, Dolashka-Angelova P (2010) Structure of hemocyanin from garden snail Helix lucorum. Comp Biochem Physiol B Biochem Mol Biol 157:16-25

Serangeli C, Bicanic O, Scheible MH, Wernet D, Lang P, Rammensee HG, Stevanovic S, Handgretinger R, Feuchtinger T (2010) Ex vivo detection of adenovirus specific CD4+ T-cell responses to HLA-DR-epitopes of the Hexon protein showed a contracted specificity of T-helper cells following stem cell transplantation. Virology 397:277-284 


Schmidt SM, König T, Bringmann A, Held S, von Schwarzenberg K, Heine A, Holderried TA, Stevanovic S, Grünebach F, Brossart P (2009) Characterization of BAX inhibitor-1 as a novel leukemia-associated antigen. Leukemia 23:1818-1824

Jäkel S, Kuckelkorn U, Szalay G, Plötz M, Textoris-Taube K, Opitz E, Klingel K, Stevanovic S, Kandolf R, Kotsch K, Stangl K, Kloetzel PM, Voigt A (2009) Differential interferon responses enhance viral epitope generation by myocardial immunoproteasomes in murine enterovirus myocarditis. Am J Pathol 175:510-518

Kloor D, Hermes M, Kirschler J, Müller M, Hagen N, Kalbacher H, Stevanovic S, Osswald H (2009) Determinants for the cAMP-binding site at the S-adenosylhomocysteine-hydrolase. Naunyn Schmiedebergs Arch Pharmacol 380:215-222

Fissolo N, Haag S, de Graaf KL, Drews O, Stevanovic S, Rammensee HG, Weissert R (2009) Naturally presented peptides on major histocompatibility complex I and II molecules eluted from central nervous system of multiple sclerosis patients. Mol Cell Proteomics 8:2090-2101 

Dolashka-Angelova P, Lieb B, Velkova L, Heilen N, Sandra K, Nikolaeva-Glomb L, Dolashki A, Galabov AS, Beeumen JV, Stevanovic S, Voelter W, Devreese B (2009) Identification of glycosylated sites in Rapana hemocyanin by mass spectrometry and gene sequence, and their antiviral effect. Bioconjug Chem 20:1315-1322

Meyer VS, Drews O, Günder M, Hennenlotter J, Rammensee HG, Stevanovic S (2009) Identification of natural MHC class II presented phosphopeptides and tumor-derived MHC class I phospholigands. J Proteome Res 8:3666-3674

Asemissen AM, Haase D, Stevanovic S, Busse A, Thiel E, Rammensee HG, Keilholz U, Scheibenbogen C (2009) Identification of an immunogenic HLA-A*02-binding T cell epitope of the transcription factor PAX2. J Immunother 32:370-375

Feuchtinger M, Christ S, Preuss B, Dengjel J, Duman S, Stevanovic S, Klein R (2009) Detection of novel non-M2-related antimitochondrial antibodies in patients with anti-M2 negative primary biliary cirrhosis. Gut 58:983-989

Feyerabend S, Stevanovic S, Gouttefangeas C, Wernet D, Hennenlotter J, Bedke J, Dietz K, Pascolo S, Kuczyk M, Rammensee HG, Stenzl A (2009) Novel multi-peptide vaccination in HLA-A2+ hormone sensitive patients with biochemical relapse of prostate cancer. Prostate 69:917-927

Marinova M, Dolashki A, Altenberend F, Stevanovic S, Voelter W, Tchorbanov B (2009) Purification and characterization of L-phenylalanine aminopeptidase from chick-pea cotyledons (Cicer arietinum L.). Protein Pept Lett 16:207-212

Stickel JS, Weinzierl AO, Hillen N, Drews O, Schuler MM, Hennenlotter J, Wernet D, Müller CA, Stenzl A, Rammensee HG, Stevanovic S (2009) HLA ligand profiles of primary renal cell carcinoma maintained in metastases. Cancer Immunol Immunother 58:1407-1417

Kapp M, Stevanovic S, Fick K, Tan SM, Löffler J, Opitz A, Tonn T, Stuhler G, Einsele H, Grigoleit GU (2009) CD8+ T-cell responses to tumor-associated antigens correlate with superior relapse-free survival after allo-SCT. Bone Marrow Transplant 43:399-410

Loeffler J, Haddad Z, Bonin M, Romeike N, Mezger M, Schumacher U, Kapp M, Gebhardt F, Grigoleit GU, Stevanovic S, Einsele H, Hebart H (2009) Interaction analyses of human monocytes co-cultured with different forms of Aspergillus fumigatus. J Med Microbiol 58:49-58


Hillen N, Mester G, Lemmel C, Weinzierl AO, Müller M, Wernet D, Hennenlotter J, Stenzl A, Rammensee HG, Stevanovic S (2008) Essential differences in ligand presentation and T cell epitope recognition among HLA molecules of the HLA-B44 supertype. Eur J Immunol 38:2993-3003

Dolashka-Angelova P, Stefanova T, Livaniou E, Velkova L, Klimentzou P, Stevanovic S, Salvato B, Neychev H, Voelter W (2008) Immunological potential of Helix vulgaris and Rapana venosa hemocyanins. Immunol Invest 37:822-840

Meyer VS, Kastenmüller W, Gasteiger G, Franz-Wachtel M, Lamkemeyer T, Rammensee HG, Stevanovic S, Sigurdardottir D, Drexler I (2008) Long-term immunity against actual poxviral HLA ligands as identified by differential stable isotope labeling. J Immunol 181:6371-6383

Droebner K, Haasbach E, Fuchs C, Weinzierl AO, Stevanovic S, Büttner M, Planz O (2008)  Antibodies and CD4+ T-cells mediate cross-protection against H5N1 influenza virus infection in mice after vaccination with a low pathogenic H5N2 strain. Vaccine 26:6965-6974

Carralot JP, Lemmel C, Stevanovic S, Pascolo S (2008) Mass spectrometric identification of an HLA-A*0201 epitope from Plasmodium falciparum MSP-1. Int Immunol 20:1451-1456

Yokoyama Y, Grünebach F, Schmidt SM, Heine A, Häntschel M, Stevanovic S, Rammensee HG, Brossart P (2008) Matrilysin (MMP-7) is a novel broadly expressed tumor antigen recognized by antigen-specific T cells. Clin Cancer Res 14:5503-5511

Weinzierl AO, Rudolf D, Maurer D, Wernet D, Rammensee HG, Stevanovic S, Klingel K (2008) Identification of HLA-A*01- and HLA-A*02-restricted CD8+ T-cell epitopes shared among group B enteroviruses. J Gen Virol 89:2090-2097

Waldhauer I, Göhlsdorf D, Gieseke F, Weinschenk T, Wittenbrink M, Ludwig A, Stevanovic S, Rammensee HG, Steinle A (2008) Tumor-associated MICA is shed by ADAM proteases. Cancer Res 68:6368-6376

Dolashki A, Velkova L, Atanasov B, Voelter W, Stevanovic S, Schwarz H, Di Muro P, Dolashka-Angelova P (2008) Reversibility and "pH-T phase diagrams" of Rapana venosa hemocyanin and its structural subunits. Biochim Biophys Acta 1784:1617-1624

Sun Y, Song M, Jäger E, Schwer C, Stevanovic S, Flindt S, Karbach J, Nguyen XD, Schadendorf D, Cichutek K (2008) Human CD4+ T lymphocytes recognize a vascular endothelial growth factor receptor-2-derived epitope in association with HLA-DR. Clin Cancer Res 14:4306-4315

Weinzierl AO, Szalay G, Wolburg H, Sauter M, Rammensee HG, Kandolf R, Stevanovic S, Klingel K (2008) Effective chemokine secretion by dendritic cells and expansion of cross-presenting CD4-/CD8+ dendritic cells define a protective phenotype in the mouse model of coxsackievirus myocarditis. J Virol 82:8149-8160

Tschiedel S, Gentilini C, Lange T, Wölfel C, Wölfel T, Lennerz V, Stevanovic S, Rammensee HG, Huber C, Cross M, Niederwieser D (2008) Identification of NM23-H2 as a tumour-associated antigen in chronic myeloid leukaemia. Leukemia 22:1542-1550

Weinzierl AO, Rudolf D, Hillen N, Tenzer S, van Endert P, Schild H, Rammensee HG, Stevanovic S (2008) Features of TAP-independent MHC class I ligands revealed by quantitative mass spectrometry. Eur J Immunol 38:1503-1510

Feldhahn M, Thiel P, Schuler MM, Hillen N, Stevanovic S, Rammensee HG, Kohlbacher O (2008) EpiToolKit - a web server for computational immunomics. Nucleic Acids Res 36:W519-522

Marinova M, Dolashki A, Altenberend F, Stevanovic S, Voelter W, Tchorbanov B (2008) Characterization of an aminopeptidase and a proline imidopeptidase from cabbage leaves. Z Naturforsch 63c:105-112

Weinzierl AO, Maurer D, Altenberend F, Schneiderhan-Marra N, Klingel K, Schoor O, Wernet D, Joos T, Rammensee HG, Stevanovic S (2008) A cryptic vascular endothelial growth factor T-cell epitope: Identification and characterization by mass spectrometry and T-cell assays. Cancer Res 68:2447-2454

Thedieck C, Kalbacher H, Kratzer U, Lammers R, Stevanovic S, Klein G (2008) Alpha B-crystallin is a cytoplasmic interaction partner of the kidney-specific cadherin-16. J Mol Biol 378:145-153

Hristova R, Dolashki A, Voelter W, Stevanovic S, Dolashka-Angelova P (2008) o-Diphenol oxidase activity of molluscan hemocyanins. Comp Biochem Physiol B Biochem Mol Biol 149:439-446

Krumova E, Dolashki A, Pashova S, Dolashka-Angelova P, Stevanovic S, Hristova R, Stefanova L, Voelter W, Angelova M (2008) Unusual location and characterization of Cu/Zn-containing superoxide dismutase from filamentous fungus Humicola lutea. Arch Microbiol 189:121-130  

Britten CM, Gouttefangeas C, Welters MJ, Pawelec G, Koch S, Ottensmeier C, Mander A, Walter S, Paschen A, Müller-Berghaus J, Haas I, Mackensen A, Kollgaard T, Thor Straten P, Schmitt M, Giannopoulos K, Maier R, Veelken H, Bertinetti C, Konur A, Huber C, Stevanovic S, Wölfel T, van der Burg SH (2008) The CIMT-monitoring panel: A two-step approach to harmonize the enumeration of antigen-specific CD8+ T lymphocytes by structural and functional assays. Cancer Immunol Immunother 57:289-302

Rudolf D, Silberzahn T, Walter S, Maurer D, Engelhard J, Wernet D, Bühring HJ, Jung G, Kwon BS, Rammensee HG, Stevanovic S (2008) Potent costimulation of human CD8 T cells by anti-4-1BB and anti-CD28 on synthetic artificial antigen presenting cells. Cancer Immunol Immunother 57:175-183


Wahlström J, Dengjel J, Persson B, Duyar H, Rammensee HG, Stevanovic S, Eklund A, Weissert R, Grunewald J (2007) Identification of HLA-DR-bound peptides presented by human bronchoalveolar lavage cells in sarcoidosis. J Clin Invest 117:3576-3582

Preuß B, Berg C, Altenberend F, Gregor M, Stevanovic S, Klein R (2007) Demonstration of autoantibodies to recombinant human sulphite oxidase in patients with chronic liver disorders and analysis of their clinical relevance. Clin Exp Immunol 150:312-321

Beck A, Hillen N, Dolashki A, Stevanovic S, Salvato B, Voelter W, Dolashka-Angelova P (2007) Oligosaccharide structure of a functional unit RvH1-b of Rapana venosa hemocyanin using HPLC/Electrospray Ionization Mass Spectrometry. Biochimie 89:938-949

Godefroy E, Wang Y, Souleimanian NE, Scotto L, Stevanovic S, Chen YT, Valmori D, Ayyoub M (2007) Assessment of CD4+ T cells specific for the tumor antigen SSX-1 in cancer-free individuals. Cancer Immunol Immunother 56:1183-1192

Boss CN, Grünebach F, Brauer K, Häntschel M, Mirakaj V, Weinschenk T, Stevanovic S, Rammensee HG, Brossart P (2007) Identification and characterization of T-cell epitopes deduced from RGS5, a novel broadly expressed tumor antigen. Clin Cancer Res 13:3347-3355

Skopeliti M, Kratzer U, Altenberend F, Panagiotou G, Kalbacher K, Stevanovic S, Voelter W, Tsitsilonis OE (2007) Proteomic exploitation on Prothymosin α-induced mononuclear cell activation. Proteomics 7:1814-1824

Schmitz M, Temme A, Senner V, Ebner R, Schwind S, Stevanovic S, Wehner R, Schackert G, Schackert HK, Füssel M, Bachmann M, Rieber EP, Weigle B (2007) Identification of SOX2 as a novel glioma-associated antigen and potential target for T-cell based immunotherapy. Br J Cancer 96:1293-1302 (Corrigendum 1928)

Dolashka-Angelova P, Stevanovic S, Dolashki A, Devreese B, Tzvetkova B, Voelter W, van Beeumen J, Salvato B (2007) A challenging insight on the structural unit I of molluscan Rapana venosa hemocyanin, Arch Biochem Biophys 459:50-58

Weinzierl A, Lemmel C, Schoor O, Müller M, Krüger T, Wernet D, Hennenlotter J, Stenzl A, Klingel K, Rammensee HG, Stevanovic S (2007) Distorted relation between mRNA copy number and corresponding major histocompatibility complex ligand density on the cell surface. Mol Cell Proteomics 6:102-113

Schmitz M, Wehner R, Stevanovic S, Kiessling A, Rieger MA, Temme A, Bachmann M, Rieber EP, Weigle B (2007) Identification of a naturally processed T cell epitope derived from the glioma-associated protein SOX11. Cancer Lett 245:331-336


Asemissen AM, Keilholz U, Tenzer S, Müller M, Walter S, Stevanovic S, Schild H, Letsch A, Thiel E, Rammensee HG, Scheibenbogen C (2006) Ex vivo T cell screening and in vitro T cell generation following regulatory T cell depletion: Identification of a highly immunogenic HLA-A*01-binding T cell epitope of WT1. Clin Cancer Res 12:7476-7482

Rückrich T, Brandenburg J, Cansier A, Müller M, Stevanovic S, Schilling K, Wiederanders B, Beck A, Melms A, Reich M, Driessen C, Kalbacher H (2006) Specificity of human cathepsin S determined by processing of peptide substrates and MHC class II-associated invariant chain. Biol Chem 387:1503-1511

Dengjel J, Nastke MD, Gouttefangeas C, Gitsioudis G, Schoor O, Altenberend F, Müller M, Krämer B, Missiou A, Sauter M, Hennenlotter J, Wernet D, Stenzl A, Rammensee HG, Klingel K, Stevanovic S (2006) Unexpected abundance of HLA class II presented peptides in primary renal cell carcinomas. Clin Cancer Res 12:4163-4170

Knights AJ, Weinzierl AO, Flad T, Guinn BA, Mueller L, Mufti GJ, Stevanovic S, Pawelec G (2006) A novel MHC-associated Proteinase 3 peptide isolated from primary chronic myeloid leukaemia cells further supports the significance of this antigen for the immunotherapy of myeloid leukaemias. Leukemia 20:1067-1072

Gückel B, Rentzsch C, Nastke MD, Marmé A, Gruber I, Stevanovic S, Kayser S, Wallwiener D (2006) Pre-existing T-cell immunity against mucin-1 in breast cancer patients and healthy volunteers. J Cancer Res Clin Oncol 132:265-274

Baechle D, Flad T, Cansier A, Steffen H, Schittek B, Tolson J, Herrmann T, Dihazi H, Beck A, Müller GA, Müller M, Stevanovic S, Garbe C, Müller CA, Kalbacher H (2006) Cathepsin D Is present in human eccrine sweat and involved in the postsecretory processing of the antimicrobial peptide DCD-1L. J Biol Chem 281:5406-5415

Sun Y, Stevanovic S, Song M, Schwantes A, Kirkpatrick JC, Schadendorf D, Cichutek K (2006) The kinase insert domain-containing receptor is an angiogenesis-associated antigen recognized by human cytotoxic T lymphocytes. Blood 107:1476-1483

Rieg S, Seeber S, Steffen H, Humeny A, Kalbacher H, Stevanovic S, Kimura A, Garbe C, Schittek B (2006) Generation of multiple stable dermcidin-derived antimicrobial peptides in sweat of different body sites. J Invest Dermatol 126:354-365  

Bruder D, Nussbaum AK, Gakamsky DM, Schirle M, Stevanovic S, Singh-Jasuja H, Darji A, Chakraborty T, Schild H, Pecht I, Weiss S (2006) Multiple synergizing factors contribute to the strength of the CD8+ T cell response against listeriolysin O. Int Immunol 18:89-100


Schuler MM, Dönnes P, Nastke MD, Kohlbacher O, Rammensee HG, Stevanovic S (2005) SNEP: SNP-derived epitope prediction program for minor H antigens. Immunogenetics 57:816-820

Neumann F, Wagner C, Preuss KD, Kubuschok B, Schormann C, Stevanovic S, Pfreundschuh M (2005) Identification of an epitope derived from the cancer testis antigen  HOM-TES-14/SCP1 and presented by dendritic cells to circulating CD4+ T cells. Blood 106:3105-3113

Oehlrich N, Devitt G, Linnebacher M, Schwitalle Y, Großkinski S, Stevanovic S, Zöller M (2005) Generation of RAGE-1 and MAGE-9 peptide-specific cytotoxic T lymphocyte lines for transfer in patients with renal cell carcinoma. Int J Cancer 117:256-264

Walter S, Bioley G, Bühring HJ, Koch S, Wernet D, Zippelius A, Pawelec G, Romero P, Stevanovic S, Rammensee HG, Gouttefangeas G (2005) High frequencies of functionally impaired cytokeratin 18-specific CD8+ T cells in healthy HLA-A2+ donors. Eur J Immunol 35:2876-2885

Paschen A, Jing W, Drexler I, Klemm M, Song M, Müller-Berghaus J, Nguyen XD, Osen W, Stevanovic S, Sutter G, Schadendorf D (2005) Melanoma patients respond to a new HLA-A*01-presented antigenic ligand derived from a multi-epitope region of melanoma antigen TRP-2. Int J Cancer 116:944-948

Dengjel J, Rammensee HG, Stevanovic S (2005) Glycan side chains on naturally presented MHC class II ligands. J Mass Spectrom 40:100-104

Dolashka-Angelova P, Dolashki A, Savvides SN, Hristova R, Van Beeumen J, Voelter W, Devreese B, Weser U, Di Muro P, Salvato B, Stevanovic S (2005) Structure of hemocyanin subunit CaeSS2 of the crustacean mediterranean crab Carcinus aestuarii. J Biochem 138:303-312

Krämer BF, Schoor O, Krüger T, Reichle C, Müller M, Weinschenk T, Hennenlotter J, Stenzl A, Rammensee HG, Stevanovic S (2005) MAGED4 – Expression in renal cell carcinoma and identification of an HLA-A*25-restricted MHC class I ligand from solid tumor tissue. Cancer Biol Ther 4:943-948

Krüger T, Schoor O, Lemmel C, Krämer BF, Reichle C, Dengjel J, Weinschenk T, Müller M, Hennenlotter J, Stenzl A, Rammensee HG, Stevanovic S (2005) Lessons to be learned from primary renal cell carcinomas: Novel tumor antigens and HLA ligands for immunotherapy. Cancer Immunol Immunother 54:826-836

Tammiruusu A, Haveri A, Pascolo S, Lahesmaa R, Stevanovic S, Rammensee HG, Sarvas M, Puolakkainen M, Vuola JM (2005) Clearance of Chlamydia pneumoniae infection in H-2 class I human leukocyte antigen-A2.1 monochain transgenic mice. Scand J Immunol 62:131-139

Dittmann J, Keller-Matschke K, Weinschenk T, Kratt T, Heck T, Becker HD, Stevanovic S, Rammensee HG, Gouttefangeas C (2005) Predominant CD8+ T-cell response against the MUC1 protein in gastrointestinal cancer survivors. Cancer Immunol Immunother 54:750-758

Dengjel J, Schoor O, Fischer R, Reich M, Kraus M, Müller M, Kreymborg K, Altenberend F, Brandenburg J, Kalbacher H, Brock R, Driessen C, Rammensee HG, Stevanovic S (2005) Autophagy promotes MHC class II presentation of peptides from intracellular source proteins. Proc Natl Acad Sci USA 102:7922-7927

Carralot JP, Dumrese C, Wessel R, Riessen R, Autenrieth I, Walter S, Schoor O, Stevanovic S, Rammensee HG, Pascolo S (2005) CD8+ T-cells specific for a potential HLA-A*0201 epitope from Chlamydophila pneumoniae are present in the PBMCs from infected patients. Int Immunol 17:591-597

Ayyoub M, Merlo A, Hesdorffer CS, Rimoldi D, Speiser D, Cerottini JC, Chen YT, Old LJ, Stevanovic S, Valmori D (2005) CD4+ T cell responses to SSX-4 in melanoma patients. J Immunol 174:5092-5099

Dolashka-Angelova P, Dolashki A, Stevanovic S, Hristova R, Atanasov B, Nikolov P, Voelter W (2005) Structure and stability of arthropodan hemocyanin Limulus polyphemus. Spectrochim Acta A Mol Biomol Spectrosc 61:1207-1217

Duyar H, Dengjel J, de Graaf KL, Wiesmüller KH, Stevanovic S, Weissert R (2005) Peptide motif for the rat MHC class II molecule RT1.Da: Similarities to the multiple sclerosis-associated HLA- immunotherapy. Cancer Immunol Immunother 54:826-836

Nastke MD, Herrgen L, Walter S, Wernet D, Rammensee HG, Stevanovic S (2005) Major contribution of codominant CD8 and CD4 T cell epitopes to the human cytomegalovirus-specific T cell repertoire. Cell Mol Life Sci 62:77-86

 Ayyoub M, Merlo A, Hesdorffer CS, Speiser D, Rimoldi D, Cerottini JC, Ritter G, Chen YT, Old LJ, Stevanovic S, Valmori D (2005) Distinct but overlapping T helper epitopes in the 37-58 region of SSX-2. Clin Immunol 114:70-78


Dengjel J, Decker P, Schoor O, Altenberend F, Weinschenk T, Rammensee HG, Stevanovic S (2004) Identification of a cyclin D1 T-helper epitope by a novel combination of HLA class II targeting and differential mass spectrometry. Eur J Immunol 34:3644-3651

Neumann F, Wagner C, Stevanovic S, Kubuschok B, Schormann C, Mischo A, Ertan K, Schmidt W, Pfreundschuh M (2004) Identification of an HLA-DR restricted peptide epitope with a promiscuous binding pattern derived from the cancer testis antigen HOM-MEL-40/SSX2. Int J Cancer 112:661-668

Voigt J, Stevanovic S, Schirle M, Fausel M, Maier J, Adam KH, Marquardt O (2004) A 14-3-3 protein of Chlamydomonas reinhardtii associated with the edoplasmic reticulum: Nucleotide sequence of the cDNA and the corresponding gene and derived amino acid sequence. Biochim Biophys Acta 1679:180-194

Neumann F, Wagner C, Kubuschok B, Stevanovic S, Rammensee HG, Pfreundschuh M (2004) Identification of an antigenic peptide derived from the cancer testis antigen NY-ESO-1 binding to a broad range of HLA-DR subtypes. Cancer Immunol Immunother 53:589-599

Schag K, Schmidt SM, Müller MR, Weinschenk T, Appel S, Weck MM, Grünebach F, Stevanovic S, Rammensee HG, Brossart P (2004) Identification of c-met oncogene as a broadly expressed tumor associated antigen recognized by cytotoxic T-lymphocytes. Clin Cancer Res 10:3658-3666

Ayyoub M, Hesdorffer CS, Metthez G, Stevanovic S, Ritter G, Chen YT, Old LJ, Speiser D, Cerottini JC, Valmori D (2004) Identification of an SSX-2 epitope presented by dendritic cells to circulating autologous CD4+ T cells. J Immunol 172:7206-7211

Burster T, Beck A, Tolosa E, Marin-Esteban V, Rötzschke O, Falk K, Lautwein A, Reich M, Brandenburg J, Schwarz G, Wiendl H, Melms A, Lehmann R, Stevanovic S, Kalbacher H, Driessen C (2004) Cathepsin G, and not asparagine endoproteinase AEP, controls the processing of myelin basic protein in lysosomes from human B lymphocytes. J Immunol 172:5495-5503

Dolashka-Angelova P, Beck A, Dolashki A, Beltramini B, Stevanovic S, Salvato B, Hristova R, Velkova L, Voelter W (2004) Carbohydrate moieties of molluscan Rapana venosa hemocyanin. Micron 35:101-104

Dolashka-Angelova P, Stevanovic S, Dolashki A, Angelova M, Serkedjieva J, Krumova E, Pashova S, Zacharieva S, Voelter W (2004) Structural and functional analysis of glycosylated Cu/Zn-superoxide dismutase from the fungal strain Humicola lutea 103. Biochem Biophys Res Commun 317:1006-1016

Lemmel C, Weik S, Eberle U, Dengjel J, Kratt T, Becker HD, Rammensee HG, Stevanovic S (2004) Differential quantitative analysis of MHC ligands by mass spectrometry using stable isotope labeling. Nat Biotechnol 22:450-454

Kircher B, Wolf M, Stevanovic S, Rammensee HG, Grubeck-Loebenstein B, Gastl G, Nachbaur D (2004) Hematopoietic Lineage-Restricted Minor Histocompatibility Antigen HA-1 in Graft-Versus-Leukemia Activity After Donor Lymphocyte Infusion. J Immunother 27:156-160

Kiessling A, Stevanovic S, Füssel S, Weigle B, Rieger MA, Temme A, Rieber EP, Schmitz M (2004) Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein prostein. Br J Cancer 90:1034-1040

Kanduc D, Fanizzi FP, Lucchese G, Stevanovic S, Sinha AA, Mittelman A (2004) NMR probing of in silico identification of anti-HPV16 E7 mAb linear peptide epitope. Peptides 25:243-250

Schmidt SM, Schag K, Müller MR, Weinschenk T, Appel S, Weck MW, Grünebach F, Kanz L,  Stevanovic S, Rammensee HG, Brossart P (2004) Induction of adipophilin specific cytotoxic T-lymphocytes using a novel HLA-A2 binding peptide that mediates tumor cell lysis. Cancer Res 64:1164-1170

Tenzer S, Stoltze L, Schönfisch B, Dengjel J, Müller M, Stevanovic S, Rammensee HG, Schild H (2004) Quantitative analysis of prion-protein degradation by constitutive and immuno-20S proteasomes indicates differences correlated with disease susceptibility. J Immunol 172:1083-1091


Schoor O, Weinschenk T, Hennenlotter J, Corvin S, Stenzl A, Rammensee HG, Stevanovic S (2003) Moderate degradation does not preclude microarray analysis of small amounts of RNA. BioTechniques 35:1192-1196, 1198-1201

Wagner C, Neumann F, Kubuschok B, Regitz E, Mischo A, Stevanovic S, Friedrich M, Schmidt W,  Rammensee HG, Pfreundschuh M (2003) Identification of an HLA-A*02 restricted immunogenic peptide derived from the cancer testis antigen HOM-MEL-40/SSX2. Cancer Immun 3:18

Walter S, Herrgen L, Schoor O, Jung G, Wernet D, Bühring HJ, Rammensee HG, Stevanovic S (2003) Cutting edge: Predetermined avidity of human CD8 T cells expanded on calibrated MHC/anti-CD28-coated microspheres. J Immunol 171:4974-4978

Rentzsch C, Kayser S, Stumm S, Watermann I, Walter S, Stevanovic S, Wallwiener D, Gückel B (2003) Evaluation of pre-existent immunity in patients with primary breast cancer: Molecular and cellular assays to quantify antigen-specific T lymphocytes in peripheral blood mononuclear cells. Clin Cancer Res 9:4376-4386 

Hebart H, Rauser G, Stevanovic S, Haenle C, Nussbaum AK, Meisner C, Bissinger AL, Tenzer S, Jahn G, Loeffler J, Rammensee HG, Schild H, Einsele H (2003) A CTL epitope from human cytomegalovirus IE1 defined by combining prediction of HLA binding and proteasomal processing is the target of dominant immune responses in patients after allogeneic stem cell transplantation. Exp Hematol 31:966-973

Tolosa E, Li W, Yasuda Y, Wienhold W, Denzin LK, Lautwein A, Driessen C, Schnorrer P, Weber E, Stevanovic S, Kurek R, Melms A, Brömme D (2003) Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis. J Clin Invest 112:517-526

Kießling A, Füssel S, Schmitz M, Stevanovic S, Meye A, Weigle B, Klenk U, Wirth MP, Rieber EP (2003) Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein trp-p8. Prostate 56:270-279

Dolashka-Angelova P, Beck A, Dolashki A, Beltramini M, Stevanovic S, Salvato B, Voelter W (2003) Characterization of the carbohydrate moieties of the functional unit RvH 1-a of Rapana venosa hemocyanin using HPLC/Electrospray ionization mass spectrometry and glycosidase digestions. Biochem J 374:185-192

Ouyang Q, Wagner WM, Walter S, Müller CA, Wikby A, Aubert G, Klatt T, Stevanovic S, Dodi T, Pawelec G (2003) An age-related increase in the number of CD8(+) T cells carrying receptors for an immunodominant Epstein-Barr virus (EBV) epitope is counteracted by a decreased frequency of their antigen-specific responsiveness. Mech Ageing Dev 124:477-485

Lucchese A, Stevanovic S, Sinha AA, Mittelman A, Kanduc D (2003) Role of MHC II affinity and molecular mimicry in defining anti-HER-2/neu MAb-3 linear peptide epitope. Peptides 24:193-197

Dolashka-Angelova P, Schwarz H, Dolashki A, Stevanovic S, Fecker M, Saeed M, Voelter W (2003) Oligomeric stability of Rapana venosa hemocyanin (RvH) and its structural subunits. Biochim Biophys Acta 1646:77-85 

Drexler I, Staib C, Kastenmüller W, Stevanovic S, Schmidt B, Lemonnier FA, Rammensee HG, Busch DH, Bernhard H, Erfle V, Sutter G (2003) Identification of vaccinia virus epitope-specific HLA-A*0201-restricted T cells and comparative analysis of smallpox vaccines. Proc Natl Acad Sci USA 100:217-222


Kießling A, Schmitz M, Stevanovic S, Weigle B, Hölig K, Füssel M, Füssel S, Meye A, Wirth MP, Rammensee HG, Rieber EP (2002) Prostate Stem Cell Antigen: Identification of immunogenic peptides and assessment of reactive CD8+ T cells in prostate cancer patients. Int J Cancer 102:390-397

Weinschenk T, Gouttefangeas C, Schirle M, Obermayr F, Walter S, Schoor O, Kurek R, Loeser W,  Bichler KH, Wernet D, Stevanovic S, Rammensee HG (2002) Integrated functional genomics approach for the design of patient-individual antitumor vaccines. Cancer Res 62:5818-5827

Münz C, Hofmann M, Yoshida K, Moustakas AK, Kikutani H, Stevanovic S, Papadopoulos GK, Rammensee HG (2002) Peptide analysis, stability studies, and structural modeling explain contradictory peptide motifs and unique properties of the NOD mouse MHC class II molecule H2-Ag7. Eur J Immunol 32:2105-2116

Höltzel A, Schmid DG, Nicholson GJ, Stevanovic S, Schimana J, Gebhardt K, Fiedler HP, Jung G (2002) Arylomycins A and B, new biaryl-bridged lipopeptide antibiotics produced by Streptomyces sp. TÜ 6075. II. Structure elucidation. J Antibiot 55: 571-577

Paludan C, Bickham K, Nikiforow S, Tsang ML, Goodman K, Hanekom WA, Fonteneau JF, Stevanovic S, Münz C (2002) Epstein-Barr nuclear antigen 1-specific CD4+ Th1 cells kill Burkitt's lymphoma cells. J Immunol 169:1593-1603

Lang KS, Moris A, Gouttefangeas C, Walter S, Teichgräber V, Müller M, Wernet D, Hamprecht K, Rammensee HG, Stevanovic S (2002) High frequency of HCMV-specific CD8+ T cells detected in a healthy CMV-seropositive donor. Cell Mol Life Sci 59:1076-1080

Saren A, Pascolo S, Stevanovic S, Dumrese T, Puolakkainen M, Sarvas M, Rammensee HG, Vuola JM (2002) Identification of Chlamydia pneumoniae-derived mouse CD8 epitopes. Infect Immun 70:3336-3343

Kircher B, Stevanovic S, Urbanek M, Mitterschiffthaler A, Rammensee HG, Grünewald K, Gastl G, Nachbaur D (2002) Induction of HA-1-specific cytotoxic T cell clones parallels the therapeutic effect of donor lymphocyte infusion (DLI). Br J Haematol 117:935-939

Sanjeevi CB, Lybrand TP, Stevanovic S, Rammensee HG (2002) Molecular modeling of eluted peptides from DQ6 molecules (DQB1*0602 and DQB1*0604) negatively and positively associated with type 1 diabetes. Ann N Y Acad Sci 958:317-320

Sun Y, Sijts AJ, Song M, Janek K, Nussbaum AK, Kral S, Schirle M, Stevanovic S, Paschen A, Schild H, Kloetzel PM, Schadendorf D (2002) Expression of the proteasome activator PA28 rescues the presentation of a cytotoxic T lymphocyte epitope on melanoma cells. Cancer Res 62:2875-2882

Hebart H, Daginik S, Stevanovic S, Grigoleit U, Dubler A, Zink M, Sinzger C, Jahn G, Loeffler J, Kanz L, Rammensee HG, Einsele H (2002) Sensitive detection of HCMV peptide-specific CTL-responses by INF- ELISPOT and flow cytometry in healthy individuals and patients following allogeneic stem cell transplantation. Blood 99:3830-3837

Ayyoub M, Stevanovic S,  Sahin U, Guillaume P, Servis C, Rimoldi D, Valmori D, Romero P, Cerottini JC, Rammensee HG, Pfreundschuh M, Speiser D, Levy F (2002) Proteasome-assisted identification of a SSX-2 derived epitope recognized by tumor reactive CTL infiltrating metastatic melanoma. J Immunol 168:1717-1722

Scheibenbogen C, Sun Y, Keilholz U, Song M, Stevanovic S, Asemissen AM, Nagorsen D, Thiel E, Rammensee HG, Schadendorf D (2002) Identification of known and novel immunogenic T cell epitopes from tumor antigens recognized by peripheral blood T cells from patients responding to IL-2-based treatment. Int J Cancer 98:409-414


Beck H, Schwarz G, Schröter CJ, Deeg M, Baier D, Stevanovic S, Weber E, Driessen C, Kalbacher H (2001) Cathepsin S and an asparagine-specific endoprotease dominate the proteolytic processing of human myelin basic protein in vitro. Eur J Immunol 31:3726-3736

Schittek B, Hipfel R, Sauer B, Bauer J, Kalbacher H, Stevanovic S, Schirle M, Schroeder K, Blin N, Meier F, Rassner G, Garbe C (2001) Dermcidin: a novel human antibiotic peptide secreted by sweat glands and transported via sweat to the skin surface. Nat Immunol 2:1133-1137

Weth R, Christ O, Stevanovic S, Zöller M (2001) Gene delivery by attenuated Salmonella typhimurium: Comparing the efficacy of helper versus cytotoxic T cell priming in tumor vaccination. Cancer Gene Ther 8:599-611

Moris A, Wernet D, Stevanovic S, Rammensee HG (2001) The peptide-specific alloreactive human T cell repertoire varies largely between individuals and is not extended in HLA-A*0205-anti-HLA-A*0201 pairings. Int Immunol 13:863-870

Toes REM, Nussbaum AK, Schirle M, Kraft M, Emmerich N, Zwinderman A, Dick TP, Müller J, Schoenfisch B, Stevanovic S, Rammensee HG, Schild H (2001) Quantitative analysis of the cleavage specificities of human 20S constitutive and immunoproteasome. J Exp Med 194:1-12

Pascolo S, Schirle M, Gückel B, Dumrese T, Stumm S, Kayser S, Moris A, Wallwiener D, Rammensee HG, Stevanovic S (2001) A MAGE-A1 HLA-A*0201 epitope identified by mass spectrometry. Cancer Res 61:4072-4077

Holo H, Jeknic Z, Daeschel M, Stevanovic S, Nes IF (2001) Plantaricin W from Lactobacillus plantarum belongs to a new family of two-peptide lantibiotics. Microbiology 147:643-651

Lang KS, Caroli CC, Muhm A, Wernet D, Moris A, Schittek B, Knauss-Scherwitz E, Stevanovic S, Rammensee HG, Garbe C (2001) HLA-A2 restricted, melanocyte specific CD8+ T lymphocytes detected in vitiligo patients are related to disease activity and are predominantly directed against MelanA/Mart1. J Invest Dermatol 116:891-897

Kleihauer A, Grigoleit U, Hebart H, Moris A, Brossart P, Muhm A, Stevanovic S, Rammensee HG, Sinzger C, Riegler S, Jahn G, Kanz L, Einsele H (2001) Ex-vivo generation of human cytomegalovirus-specific cytotoxic T cells by peptide-pulsed dendritic cells. Br J Haematol 113:231-239

Planz O, Dumrese T, Hülpüsch S, Schirle S, Stevanovic S, Stitz L (2001) A naturally processed rat MHC class I - associated viral peptide as target structure of Borna disease virus specific CD8+ T cells. J Biol Chem 276:13689-13694

Stevanovic S, Bohley P (2001) Proteome analysis by three-dimensional protein separation: Turnover of cytosolic proteins in hepatocytes. Biol Chem 382:677-682

Flieger A, Gong S, Faigle M, Stevanovic S, Cianciotto NP, Neumeister B (2001) Legionella pneumophila secretes different phospholipase A activities. J Bacteriol 183:2121-2124

Schmittel A, Keilholz U, Bauer S, Kuhne U, Stevanovic S, Thiel E, Scheibenbogen C (2001) Analysis of T cell responses against protein antigens with the IFN- ELISPOT assay. J Immunol Methods 247:17-24


Stoltze L, Schirle M, Schwarz G, Schröter C, Thompson MW, Hersh LB, Kalbacher H, Stevanovic S, Rammensee HG, Schild H (2000) Two new proteases in the MHC class I processing pathway. Nat Immunol 1:413-418

Kastrup IB, Stevanovic S, Arsequell G, Valencia G, Zeuthen J, Rammensee HG, Elliott T, Haurum JS (2000) Lectin purified human class I MHC-derived peptides: evidence for presentation of glycopeptides in vivo. Tissue Antigens 56:129-135

Krausa P, Münz C, Keilholz W, Stevanovic S, Jones EY, Browning M, Bunce M, Rammensee HG, McMichael A (2000) Definition of peptide binding motifs amongst the HLA-A*30 allelic group. Tissue Antigens 56:10-18

Wienhold W, Malcherek G, Jung C, Stevanovic S, Jung G, Schild H, Melms A (2000) An example of immunodominance: engagement of synonymous TCR by invariant CDR3. Int Immunol 12:747-756

Schmitz M, Diestelkoetter P, Weigle B, Schmachtenberg F, Stevanovic S, Ockert D, Rammensee HG, Rieber EP (2000) Generation of survivin-specific CD8+ T effector cells by dendritic cells pulsed with protein or selected peptides. Cancer Res 60:4845-4849

Emmerich NP, Nussbaum AK, Stevanovic S, Priemer M, Toes RE, Rammensee HG, Schild H (2000) The human 26S and 20S proteasomes generate overlapping but different sets of peptide fragments from a model protein substrate. J Biol Chem 275:21140-21148

Schirle M, Keilholz W, Weber B, Gouttefangeas C, Dumrese T, Becker HD, Stevanovic S, Rammensee HG (2000) Identification of tumor-associated MHC class I ligands by a novel T cell-independent approach. Eur J Immunol 30:2216-2225

Sun Y, Song M, Stevanovic S, Jankowiak C, Paschen A, Rammensee HG, Schadendorf D (2000) Identification of a new HLA-A2.1-restricted T cell epitope from the tyrosinase-related protein 2 (TRP2) melanoma antigen. Int J Cancer 87:399-404

Gouttefangeas C, Diehl M, Keilholz W, Hörnlein RF, Stevanovic S, Rammensee HG (2000) Thrombocyte HLA molecules retain non-renewable endogenous peptides of the megakaryocyte lineage and do not stimulate direct allocytotoxicity in vitro. Blood 95:3168-3175

Obst R, Netuschil N, Klopfer K, Stevanovic S, Rammensee HG (2000) The role of peptides in T cell alloreactivity is determined by self-major histocompatibility complex molecules. J Exp Med 191:805-812


Mear JP, Schreiber KL, Münz C, Zhu X, Stevanovic S, Rammensee HG, Rowland-Jones SL, Colbert RA (1999) Misfolding of HLA-B27 as a result of its B pocket suggests a novel mechanism for its role in susceptibility to spondyloarthropathies. J Immunol 163:6665-6670

Rammensee HG, Bachmann J, Emmerich N, Bachor OA, Stevanovic S (1999) SYFPEITHI: database for MHC ligands and peptide motifs. Immunogenetics 50:213-219

Seeger FH, Schirle M, Keilholz W, Rammensee HG, Stevanovic S(1999) Peptide motif of HLA-B*1510. Immunogenetics 49:996-999

Münz C, Stevanovic S, Rammensee HG (1999) Peptide presentation and NK inhibition by HLA-G. J Reprod Immunol 43:139-155

Brossart P, Heinrich KS, Stuhler G, Behnke L, Reichardt VL, Stevanovic S, Muhm A, Rammensee HG, Kanz L, Brugger W (1999) Identification of HLA-A2 restricted T cell epitopes derived from the MUC1 tumor antigen for broadly applicable vaccine therapies. Blood 93:4309-4317

Seeger FH, Schirle M, Gatfield J, Arnold D, Keilholz W, Nickolaus P, Rammensee HG, Stevanovic S (1999) The HLA-A*6601 peptide motif. Prediction by pocket structure and verification by peptide analysis. Immunogenetics 49:571-576

Stuhler G, Zobywalski A, Grünebach F, Brossart P, Reichardt VL, Barth H, Stevanovic S, Brugger W, Kanz L, Schlossman SF (1999) Immune regulatory loops determine productive interactions within human T lymphocyte-dendritic cell clusters. Proc Natl Acad Sci USA 96:1532-1535

Münz C, Obst R, Osen W, Stevanovic S, Rammensee HG (1999) Alloreactivity as a source of high avidity peptide-specific human CTL. J Immunol 162:25-34


Gatfield J, Lammert E, Nickolaus P, Münz C, Rothenfusser S, Fisch P, Stevanovic S, Schild H, Rammensee HG, Arnold D (1998) Cell lines transfected with the TAP inhibitor ICP47 allow testing peptide binding to a variety of HLA class I molecules. Int Immunol 10:1665-1672

Nussbaum AK, Dick TP, Keilholz W, Schirle M, Stevanovic S, Dietz K, Heinemeyer W, Groll M, Wolf DH, Huber R, Rammensee HG, Schild H (1998) Cleavage motifs of the yeast 20S proteasome  subunits deduced from digests of enolase 1. Proc Natl Acad Sci USA 95:12504-12509

Dick TP, Nussbaum AK, Deeg M, Heinemeyer W, Groll M, Schirle M,  Keilholz W, Stevanovic S, Wolf DH, Huber R, Rammensee HG, Schild H (1998) Contribution of proteasomal -subunits to the cleavage of peptide substrates analyzed with yeast mutants. J Biol Chem 273:25637-25646

Dumrese T, Stevanovic S, Seeger FH, Yamada N, Ishikawa Y, Tokunaga K, Takiguchi M, Rammensee HG (1998) HLA-A26 subtype A pockets accomodate acidic N-termini of ligands. Immunogenetics 48:350-353

Dick TP, Stevanovic S, Keilholz W, Ruppert T, Koszinowski U, Schild H, Rammensee HG (1998) The making of the dominant MHC class I ligand SYFPEITHI. Eur J Immunol 28:2478-2486

Obst R, Münz C, Stevanovic S, Rammensee HG (1998) Allo- and self-MHC-restricted cytotoxic T lymphocytes against a peptide library: evidence for a functionally diverse allorestricted T cell repertoire. Eur J Immunol 28:2432-2443

Seeger FH, Arnold D, Dumrese T, de la Salle H, Fricker D, Schild H, Rammensee HG, Stevanovic S (1998) The HLA-B*1516 motif demonstrates HLA-B-specific P2 pocket characteristics. Immunogenetics 48:156-160

Böhm CM, Hanski ML, Stevanovic S, Rammensee HG, Stein H, Taylor-Papadimitriou J, Riecken EO,  Hanski C (1998) Identification of HLA-A2-restricted epitopes of the tumor-associated antigen MUC2 recognized by human cytotoxic T cells. Int J Cancer 75:688-693

Brossart P, Stuhler G, Flad T, Stevanovic S, Rammensee HG, Kanz L, Brugger W (1998) Her-2/neu-derived peptides are tumor-associated antigens expressed by human renal cell and colon carcinoma lines and are recognized by in vitro induced specific cytotoxic T lymphocytes. Cancer Res 58:732-736


Griffin TA, Yuan J, Friede T, Stevanovic S, Ariyoshi K, Rowland-Jones SL, Rammensee HG, Colbert RA (1997) Naturally occurring A pocket polymorphism in HLA-B*2703 increases the dependence on an accessory anchor residue at P1 for optimal binding of nonamer peptides. J Immunol 159:4887-4897

Arnold D, Keilholz W, Schild H, Dumrese T, Stevanovic S, Rammensee HG (1997) Substrate specificity of cathepsins D and E determined by N-terminal and C-terminal sequencing of peptide pools. Eur J Biochem 249:171-179

Arnold D, Keilholz W, Schild H, Dumrese T, Stevanovic S, Rammensee HG (1997) Evolutionary conserved cathepsin E substrate specificity as defined by N-terminal and C-terminal sequencing of peptide pools. Biol Chem 378:883-891

Lammert E, Stevanovic S, Brunner J, Rammensee HG, Schild H (1997) Protein disulfide isomerase is the dominant acceptor for peptides translocated into the endoplasmic reticulum. Eur J Immunol 27:1685-1690

Scheibenbogen C, Lee KH, Stevanovic S, Witzens M, Willhauck M, Waldmann V, Naeher H, Rammensee HG, Keilholz U (1997) Analysis of the T cell response to tumor and viral peptide antigens by an IFN-ELISPOT assay. Int J Cancer 71:932-936

Godkin A, Friede T, Davenport M, Stevanovic S, Willis A, Jewell D, Hill A, Rammensee HG (1997) Use of eluted peptide sequence data to identify the binding characteristics of peptides to the insulin-dependent diabetes susceptibility allele HLA-DQ8 (DQ3.2). Int Immunol 9:905-911

 de la Salle H, Houssaint E, Peyrat MA, Arnold D, Salamero J, Pinczon D, Stevanovic S, Bausinger H,  Fricker D, Gomard E, Biddison W, Lehner P, UytdeHaag F, Sasportes M, Donato L, Rammensee HG, Cazenave JP, Hanau D, Tongio MM, Bonneville M (1997) Human peptide transporter deficiency: importance of HLA-B in the presentation of TAP-independent EBV antigens. J Immunol 158:4555-4563

Lammert E, Arnold D, Nijenhuis M, Momburg F, Hämmerling GJ, Brunner J, Stevanovic S, Rammensee HG, Schild H (1997) The endoplasmic reticulum resident stress protein gp96 binds peptides translocated by TAP. Eur J Immunol 27:923-927

Reizis B, Schild H, Stevanovic S, Mor F, Rammensee HG, Cohen IR (1997) Peptide binding motifs of the MHC class I molecules (RT1.AI) of the Lewis rat. Immunogenetics 45:278-279

Buseyne F, Stevanovic S, Rammensee HG, Rivière Y (1997) Characterization of an HIV-1 p24gag epitope recognized by a CD8+ cytotoxic T cell clone. Immunol lett 55:145-149

Scheibenbogen C, Lee KH, Mayer S, Stevanovic S, Moebius U, Herr W, Rammensee HG, Keilholz U (1997) A sensitive ELISPOT assay for detection of CD8+ T lymphocytes specific for HLA class I-binding peptide epitopes derived from Influenza proteins in the blood of healthy donors and melanoma patients. Clin Cancer Res 3:221-226

Davenport MP, Godkin A, Friede T, Stevanovic S, Willis AC, Hill AV, Rammensee HG (1997) A distinctive peptide motif for HLA-DRB1*0407, an HLA-DR4 subtype not associated with rheumatoid arthritis. Immunogenetics 45:229-232


Reizis B, Mor F, Eisenstein M, Schild H, Stevanovic S, Rammensee HG, Cohen IR (1996) The peptide binding specificity of the MHC class II I-A molecule of the Lewis rat, RT1.Bl. Int Immunol 8:1825-1832

Vartdal F, Johansen BH, Friede T, Thorpe CJ, Stevanovic S, Eriksen JE, Sletten K, Thorsby E, Rammensee HG, Sollid LM (1996) The peptide binding motif for the disease associated HLA-DQ (1*0501, 1*0201) molecule. Eur J Immunol 26:2764-2772

Mayer S, Scheibenbogen C, Lee KH, Keilholz W, Stevanovic S, Rammensee HG, Keilholz U (1996) A sensitive proliferation assay to determine the specific T cell response against HLA-A2.1-binding peptides. J Immunol Methods 197:131-137

Dick TP, Ruppert T, Groettrup M, Kloetzel PM, Kuehn L, Koszinowski UH, Stevanovic S, Schild H, Rammensee HG (1996) Coordinated dual cleavages induced by the proteasome regulator PA28 lead to dominant MHC ligands. Cell 86:253-262

Friede T, Gnau V, Jung G, Keilholz W, Stevanovic S, Rammensee HG (1996) Natural ligand motifs of closely related HLA-DR4 molecules predict features of rheumatoid arthritis associated peptides. Biochim Biophys Acta 1316:85-101

Merkel F, Kalluri R, Marx M, Enders U, Stevanovic S, Giegerich G, Neilson EG, Rammensee HG, Hudson BG, Weber M (1996) Autoreactive T-cells in Goodpasture’s syndrome recognize the N-terminal NC1 domain on 3 type IV collagen. Kidney Int 49:1127-1133

Diehl M, Münz C, Keilholz W, Stevanovic S, Holmes N, Loke YW, Rammensee HG (1996) Nonclassical HLA-G molecules are classical peptide presenters. Curr Biol 6:305-314

Steinle A, Falk K, Rötzschke O, Gnau V, Stevanovic S, Jung G, Schendel DJ, Rammensee HG (1996) Motif of HLA-B*3503 peptide ligands. Immunogenetics 43:105-107


Campos M, Bayer E, Gonzalez H, Schmeer K, Stevanovic S, Jouchim H, Bocaz G, Vasquez O (1995) N-terminal amino-acid sequence of -lactamase from Shigella flexneri UCSF-129. Microbios 82:217-225

Schild H, Grüneberg U, Pougialis G, Wallny HJ, Keilholz W, Stevanovic S, Rammensee HG (1995) Natural ligand motifs of H-2E molecules are allele specific and illustrate homology to HLA-DR molecules. Int Immunol 7:1957-1965

Barouch D, Friede T, Stevanovic S, Tussey L, Smith K, Rowland-Jones S, Braud V, McMichael A, Rammensee HG (1995) HLA-A2 subtypes are functionally distinct in peptide binding and presentation. J Exp Med 182:1847-1856

Bamford AI, Douglas A, Friede T, Stevanovic S, Rammensee HG, Adair BM (1995) Peptide motif of a cattle MHC class I molecule. Immunol Lett 45:129-136

Rammensee HG, Friede T, Stevanovic S (1995) MHC ligands and peptide motifs: first listing. Immunogenetics 41:178-228

Falk K, Rötzschke O, Takiguchi M, Gnau V, Stevanovic S, Jung G, Rammensee HG (1995) Peptide motifs of HLA-B51, -B52 and -B78 molecules, and implications for Behçet's disease. Int Immunol 7:223-228

Falk K, Rötzschke O, Takiguchi M, Gnau V, Stevanovic S, Jung G, Rammensee HG (1995) Peptide motifs of HLA-B58, B60, B61, and B62 molecules. Immunogenetics 41:165-168

Falk K, Rötzschke O, Takiguchi M, Gnau V, Stevanovic S, Jung G, Rammensee HG (1995) Peptide motifs of HLA-B38 and B39 molecules. Immunogenetics 41:162-164


Metzger JW, Stevanovic S, Brünjes J, Wiesmüller KH, Jung G (1994) Electrospray mass spectrometry and multiple sequence analysis of peptide libraries. Methods 6:425-431

Skaugen M, Nissen-Meyer J, Jung G, Stevanovic S, Sletten K, Inger C, Abildgaard M, Nes IF (1994) In vivo conversion of L-serine to D-alanine in a ribosomally synthesized polypeptide. J Biol Chem 269:27183-27185

Maier R, Falk K, Rötzschke O, Maier B, Gnau V, Stevanovic S, Jung G, Rammensee HG, Meyerhans A (1994) Peptide motifs of HLA-A3, -A24, and -B7 molecules as determined by pool sequencing. Immunogenetics 40:306-308

Malcherek G, Gnau V, Stevanovic S, Rammensee HG, Jung G, Melms A (1994) Analysis of allele-specific contact sites of natural HLA-DR17 ligands. J Immunol 153:1141-1149

Falk K, Rötzschke O, Stevanovic S, Gnau V, Sparbier K, Jung G, Rammensee HG, Walden P (1994) Analysis of a naturally occurring HLA class I-restricted viral epitope. Immunology 82:337-342

Falk K, Rötzschke O, Takiguchi M, Grahovac B, Gnau V, Stevanovic S, Jung G, Rammensee HG (1994) Peptide motifs of HLA-A1, -A11, -A31, and -A33 molecules. Immunogenetics 40:238-241

Jack RW, Carne A, Metzger J, Stevanovic S, Sahl HG, Jung G, Tagg J (1994) Elucidation of the structure of SA-FF22, a lanthionine-containing antibacterial peptide produced by Streptococcus pyogenes  strain FF22. Eur J Biochem 220:455-462

Falk K, Rötzschke O, Stevanovic S, Jung G, Rammensee HG (1994) Pool sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of processing, and general rules. Immunogenetics 39:230-242

Rötzschke O, Falk K, Stevanovic S, Gnau V, Jung G, Rammensee HG (1994) Dominant aromatic/ aliphatic C-terminal anchor in HLA-B*2702 and B*2705 peptide motifs. Immunogenetics 39:74-77


Falk K, Rötzschke O, Grahovac B, Schendel D, Stevanovic S, Gnau V, Jung G, Strominger JL, Rammensee HG (1993) Allele-specific peptide ligand motifs of HLA-C molecules. Proc Natl Acad Sci USA 90:12005-12009

Malcherek G, Falk K, Rötzschke O, Rammensee HG, Stevanovic S, Gnau V, Jung G, Melms A (1993) Natural peptide ligand motifs of two HLA molecules associated with myasthenia gravis. Int Immunol 5:1229-1237

Kupke T, Stevanovic S, Ottenwälder B, Metzger JW, Jung G, Götz F (1993) Purification and characterization of EpiA, the peptide substrate for post-translational modifications involved in epidermin biosynthesis. FEMS Microbiol Lett 112:43-48

Norda M, Falk K, Rötzschke O, Stevanovic S, Jung G, Rammensee HG (1993) Comparison of the H-2Kk- and H-2Kkm1-restricted peptide motifs. J Immunother 14:144-149

Peschel A, Augustin J, Kupke T, Stevanovic S, Götz F (1993) Regulation of epidermin biosynthetic genes by EpiQ. Mol Microbiol 9:31-39

Stevanovic S, Jung G (1993) Multiple Sequence Analysis: Pool sequencing of synthetic and natural peptide libraries. Anal Biochem 212:212-220

Rötzschke O, Falk K, Stevanovic S, Grahovac B, Soloski MJ, Jung G, Rammensee HG (1993) Qa-2 molecules are peptide receptors of higher stringency than ordinary class I molecules. Nature 361:642-644

Falk K, Rötzschke O, Grahovac B, Schendel D, Stevanovic S, Jung G, Rammensee HG (1993) Peptide motifs of HLA-B35 and -B37 molecules. Immunogenetics 38:161-162


Rötzschke O, Falk K, Stevanovic S, Jung G, Rammensee HG (1992) Peptide motifs of closely related HLA class I molecules encompass substantial differences. Eur J Immunol 22:2453-2456

Kuhn CS, Lehmann  J, Jung G, Stevanovic S (1992) Investigation of the active site of Escherichia coli beta-D-galactosidase by photoaffinity labelling. Carbohydr Res 232:227-233

Kupke T, Stevanovic S, Sahl HG, Götz F (1992) Purification and characterization of EpiD, a flavoprotein involved in the biosynthesis of the lantibiotic epidermin. J Bacteriol 174:5354-5361

Gebhart UB, Maier TL, Stevanovic S, Bayer MG, Schenk HE (1992) Ferredoxin:NADP oxidoreductase of Cyanophora paradoxa: Purification, partial characterization, and N-terminal amino acid sequence. Protein Expr Purif 3:228-235

Deres K, Schumacher TN, Wiesmüller KH, Stevanovic S, Greiner G, Jung G, Ploegh HL (1992) Preferred size of peptides that bind to H-2 Kb is sequence dependent. Eur J Immunol 22:1603-1608

Kropshofer H, Max H, Müller CA, Hesse F, Stevanovic S, Jung G, Kalbacher H (1992) Self-peptide released from class II HLA-DR1 exhibits a hydrophobic two-residue contact motif. J Exp Med 175:1799-1803

Schenk HE, Bayer MG, Maier TL, Lüttke A, Gebhart UB, Stevanovic S (1992) Ferredoxin-NADP+ oxidoreductase of C. paradoxa nucleus encoded, but cyanobacterial. Gene transfer from symbiont to host, an evolutionary mechanism originating new species. Z Naturforsch 47c:387-393


Rötzschke O, Falk K, Stevanovic S, Jung G, Walden P, Rammensee HG (1991) Exact prediction of a natural T cell epitope. Eur J Immunol 21:2891-2894

Falk K, Rötzschke O, Stevanovic S, Jung G, Rammensee HG (1991) Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 351:290-296

Weil HP, Beck-Sickinger AG, Metzger J, Stevanovic S, Jung G, Josten M, Sahl HG (1990) Biosynthesis of the lantibiotic Pep5. Isolation and characterization of a prepeptide containing dehydroamino acids. Eur J Biochem 194:217-223

Woitzik D, Weckesser J, Benz R, Stevanovic S, Jung G, Rosenbusch JP (1990) Porin of Rhodobacter capsulatus: Biochemical and functional characterization. Z Naturforsch 45c:576-582

Stevanovic S, Bayer MG, Tröger W, Schenk HEA (1989) Cyanophora paradoxa korsch.: Ferredoxin partial amino-terminal amino acid sequence, phylogenetic/taxonomic evidence. Endocyt Cell Res 6:219-226

Lechner M, Kupke T, Stevanovic S, Götz F (1989) Molecular characterization and sequence of phosphatidylinositol-specific phospholipase C of Bacillus thuringiensis. Mol Microbiol 3:621-626