Groups

Publications Prof. Dr. Alex Weber

Publications 2013 - 2017

2017

Stadler N, Hasibeder A, Aranda Lopez P, Desuki A, Kriege O, Weber AN, Michel C, Teschner D, Heß D, Radsak MP.  The Bruton tyrosine kinase inhibitor ibrutinib abrogates TREM-1 mediated neutrophil activation. Haematologica 2017,  pii: haematol.2016.152017.

Liu X, Pichulik T, Wolz OO, Dang TM, Stutz A, Dillen C, Delmiro Garcia M, Kraus H, Dickhöfer S, Daiber E, Münzenmayer L, Wahl S, Rieber N, Kümmerle-Deschner J, Yazdi A, Franz-Wachtel M, Macek B, Radsak M, Vogel S, Schulte B, Walz JS, Hartl D, Latz E, Stilgenbauer S, Grimbacher B, Miller L, Brunner C, Wolz C, Weber AN. Human NLRP3 inflammasome activity is regulated by and therapeutically targetable via BTK. J Allergy Clin Immunol. 2017 S0091-6749(17)30232-4.

Murthy P, Durco F, Miller-Ocuin JL, Takedai T, Shankar S, Liang X, Liu X, Cui X, Sachdev U, Rath D, Lotze MT, Zeh III HJ, Gawaz M, Weber AN, Vogel S. The NLRP3 inflammasome and Bruton's tyrosine kinase in platelets co-regulate platelet activation, aggregation, and in vitro thrombus formation. Biochem Biophys Res Commun. 2017,483(1):230-236.

Nelde A, Stickel JS, Kowalewski D, Schuster H, Wolz OO, Peper J, Cardona Gloria Y, Langerak A, Muggen A, Claus R, Bonzheim I, Fend F, Salih H, Kanz L, Rammensee HG, Stevanović S, and Weber AN. HLA class I-restricted MYD88 L265P-derived peptides as specific targets for lymphoma immunotherapy. OncoImmunology, in press (#2016ONCOIMM0175).

2016

Fischer J, Weber AN$, Böhm S, Dickhöfer S, El Maadidi S, Deichsel D, Knop V, Klinker H, Möller B, Rasenack J, Wang L, Sharma M, Hinrichsen H, Spengler U, Buggisch P, Sarrazin C, Pawlita M, Waterboer T, Wiese M, Probst-Müller E, Malinverni R, Bochud PY, Gardiner C, O’Farrelly C, Berg T$. Sex-specific effects of TLR9 promoter variants on spontaneous clearance of HCV infection. Gut. 2016; pii: gutjnl-2015-310239. $ shared senior authorship.

Dossang AC, Motshwene PG, Yang Y, Symmons MF, Bryant CE, Borman S, George J, Weber AN, Gay NJ. The N-terminal loop of IRAK-4 death domain regulates ordered assembly of the Myddosome signalling scaffold. Sci Rep. 2016 Nov 23;6:37267.

Knittel G, Liedgens P, Korovkina D, Seeger J, Al-Baldawi Y, Al-Maarri M, Fritz C, Vlantis K, Bezhanova S, Scheel AH, Wolz OO, Reimann M, Möller P, López C, Schlesner M, Lohneis P, Weber AN, Trümper L, ICGC MMML-Seq Consortium, Staudt LM, Ortmann L, Pasparakis M, Siebert R, Schmitt CA, Klatt AR, Wunderlich FT, Schäfer SC, Persigehl T, Montesinos-Rongen M, Odenthal M, Büttner R, Frenzel LP, Kashkar H, Reinhardt HC. B cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B cell lymphoma in mice. Blood. 2016; 127(22):2732-41.

2015

Wang H, El Maadidi S, Fischer J, Grabski E, Dickhöfer S, Klimosch S, Flannery SM, Filomena A, Wolz OO,  Schneiderhan-Marra N, Löffler MW, Wiese M, Pichulik T, Müllhaupt B, Semela D, Dufour J-F, the East-German and Swiss Hepatitis C Virus Study Groups, Bochud P-Y,  Bowie AG, Kalinke U, Berg T, Weber AN. A frequent hypofunctional IRAK2 variant is associated with reduced spontaneous hepatitis C virus clearance. Hepatology. 2015, 62(5):1375-87.

Pichulik T, Khatamzas E, Liu X, Brain O, Delmiro Garcia M, Leslie A, Danis B, Mayer A, Baban D, Ragoussis J, Weber AN, Simmons A.  Pattern recognition receptor mediated downregulation of microRNA-650 fine-tunes MxA expression in dendritic cells infected with influenza A virus. Eur J Immunol. 2015, Oct 8. doi: 10.1002/eji.201444970.

Rieber N, Singh A, Öz H, Carevic M, Bouzani M, Amich J, Ost M, Ye Z, Ballbach M, Schäfer I, Mezger M, Klimosch SN, Weber AN, Handgretinger R, Krappmann S, Liese J, Engeholm M, Schüle R, Salih HR, Marodi L, Speckmann C, Grimbacher B, Ruland J, Brown GD, Beilhack A, Loeffler J, Hartl D. Pathogenic fungi regulate T-cell immunity by inducing neutrophilic myeloid-derived suppressor cells through a Dectin-1/CARD9 and ROS-mediated mechanism. Cell Host Microbe. 2015, 17(4):507-14.

2014

Avbelj M*, Wolz O*, Fekonja O, Benčina M, Repič M, Mavri J, Krüger J, Schärfe C, Kohlbacher O, Weber AN$, Jerala R$. Activation of lymphoma-associated MyD88 mutations via allostery-induced TIR domain oligomerization. Blood, 2014, 124 (26): 3896-904. *equal contribution, $ shared senior authorship

Wang H, Flannery SM, Dickhöfer S, Huhn S, George J, Kubarenko AV, Lascorz J, Bevier M, Willemsen J, Pichulik T, Schafmayer C, Binder M, Manoury B, Paludan SR, Alarcon-Riquelme M, Bowie AG, Försti A, Weber AN. A coding IRAK2 variant compromises TLR signaling and is associated with colorectal cancer survival. J Biol Chem. 2014, 289 (33): 23123-31.

Weber AN, Försti A. Toll-like receptor genetic variants and colorectal cancer. OncoImmunology 2014 Jan 1;3(1):e27763.

Colak E, Leslie A, Zausmer K, Khatamzas E, Kubarenko AV, Pichulik T, Klimosch SN, Mayer A, Siggs O, Hector A, Fischer R, Klesser B, Rautanen A, Frank M, Hill AVS, Manoury B, Beutler B, Hartl D, Simmons A, Weber AN. RNA and Imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events. J Immunol. 2014, 192 (12): 5963-73.

Novikova L, Czymmeck N, Deuretzbacher A, Buck F, Richter K, Weber AN, Aepfelbacher M, Ruckdeschel K. Cell death triggered by Yersinia enterocolitica identifies processing of the proinflammatory signal adapter MyD88 as a general event in the execution of apoptosis. J Immunol. 2014 Feb 1;192(3):1209-19.

2013

Klimosch SN, Försti A, Eckert J, Knežević J, Bevier M, von Schönfels W, Heits N, Walter J, Hinz S, Lascorz J, Hampe J, Hartl D, Frick JS, Hemminki K, Schafmayer C, Weber AN. Functional TLR5 genetic variants affect human colorectal cancer survival. Cancer Res 2013;73(24):7232-42.

Eckert KJ, Kim YJ, Kim JI, Gürtler K, Oh D-Y, Sur S, Lundvall L, Hamann L, van der Ploeg A, Pickkers P, Giamarellos-Bourboulis E, Kubarenko AV, Weber AN, Kabesch M, Kumpf O, An H-J, Lee J-O and Schumann RR. The Crystal Structure of Lipopolysaccharide Binding Protein Reveals the Location of a Frequent Mutation that Impairs Innate Immunity. Immunity 2013; 39(4):647 – 660.

Over B, Ziegler S, Foermer S, Weber AN, Bode K, Heeg K and Bekeredjian-Ding I. IRAK4 turns IL-10+ phospho-FOXO+ monocytes into pro-inflammatory cells by suppression of protein kinase B. Eur J Immunol. 2013 Jun;43(6):1630-42.

schliessen

Publications 2003 -2012

2012

Paquette N, Conlon J, Sweet C, Rus F, Wilson L, Pereira A, Rosadini CV, Goutagny N, Weber AN, Lane WS, Shaffer SA, Maniatis S, Fitzgerald KA, Stuart L, Silverman N. Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12710-5.

Knežević J, Pavlinić D, Bendelja K, Gabrilovac J, Parcina M, Kubarenko AV, Petricevic B, Vrbanec D, Bulat-Kardum L, Bekeredjian-Ding I, Pavelić J, Dembić Z, Weber AN. B lymphocytes and plasmacytoid dendritic cells from carriers of dysfunctional TLR9 alleles retain CpG-oligonucleotide responsiveness. J Biol Chem. 2012 Jul 13;287(29):24544-53.

Berger M, Hsieh CY, Bakele M, Marcos V, Rieber N, Kormann M, Mays L, Hofer L, Neth O, Vitkov L, Krautgartner WD, von Schweinitz D, Kappler R, Hector A, Weber A, Hartl D. Neutrophils express distinct RNA receptors in a non-canonical way. J Biol Chem. 2012 Jun 1;287(23):19409-17.

Lenci R, Rachakonda S, Kubarenko AV, Weber AN, Brandt A, Gast A, Sucker A, Hemminki K, Schadendorf D, Kumar R. Integrin Genes and Susceptibility to Human Melanoma. Mutagenesis 2012 May;27(3):367-73.

2011

Gast A, Bermejo JL, Claus R, Brandt A, Weires M, Weber A, Plass C, Sucker A, Hemminki K, Schadendorf D, Kumar R. Association of inherited variation in toll-like receptor genes with malignant melanoma susceptibility and survival. PLoS One. 2011;6(9):e24370.

Shatnyeva OM, Kubarenko AV, Weber CE, Pappa A, Schwartz-Albiez R, Weber AN, Krammer PH, Lavrik IN. Modulation of the CD95-Induced Apoptosis: The Role of CD95 N-Glycosylation. PLoS One. 2011;6(5):e19927.

Iavarone C, Ramsauer K, Kubarenko AV, Debasitis JC, Leykin I, Weber AN, Siggs OM, Beutler B, Zhang P, Otten G, D'Oro U, Valiante NM, Mbow ML, Visintin A. A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding. J Immunol. 2011 Apr 1;186(7):4213-22.

Sytnikova Y, Kubarenko AV, Schäfer A, Weber AN, Niehrs C. Gadd45a is an RNA binding protein and is localized in nuclear speckles. PLoS One. 2011 Jan 7 7;6(1):e14500.

George J, Motshwene PG, Wang H, Kubarenko AV, Rautanen A, Mills TC, Hill AV, Gay NJ, Weber AN. Two human MYD88 variants, S34Y and R98C, interfere with MYD88-IRAK4-myddosome assembly. Biol Chem 2011, Jan 14;286(2):1341-53.

2010

Gdynia G, Keith M, Kopitz J, Bergmann M, Fassl A, Weber AN, George J, Kees T, Zentgraf HW, Wiestler OD, Schirmacher P, Roth W. Danger signaling protein HMGB1 induces a distinct form of cell death accompanied by formation of giant mitochondria. Cancer Res. 2010 Nov 1;70(21):8558-68.

Kubarenko AV, Ranjan S, Rautanen A, Mills TC, Wong S, Vannberg F, Neumaier M, Bekeredjian-Ding I, Hill AV, Ahmad-Nejad P, Weber AN. Naturally Occurring Variant in Human TLR9, P99L, Is Associated with Loss of CpG Oligonucleotide Responsiveness. J Biol Chem. 2010 Nov 19;285(47):36486-94. Epub 2010 Sep 14.

George J, Kubarenko A, Rautanen A, Mills TC, Colak E, Kempf T, Hill AVS, Nieters A, Weber AN. Mal D96N is a naturally occurring loss-of-function variant of TIRAP. J Immunol. 2010 Mar 15;184(6):3025-32

Kubarenko A, Ranjan S, Colak E, George J, Frank M, Weber AN. Comprehensive Modeling and Functional Analysis of Toll-like Receptor Ligand-Recognition Domains. Protein Sci 2010, Mar; 19(3):558-69

2009

Shia AK, Glittenberg M, Thompson G, Weber AN, Reichhart JM, Ligoxygakis P. Toll-dependent antimicrobial responses in Drosophila larval fat body require Spatzle secreted by haemocytes. J Cell Sci. 2009 Dec 15;122(Pt 24):4505-15. Epub 2009 Nov 24.

Pothlichet J, Burtey A, Kubarenko A, Caignard G, Solhonne B, Tangy F, Ben-Ali M, Quintana-Murci L, Heinzmann A, Chiche JD, Vidalain PO, Weber AN, Chignard M, Si-Tahar M. Study of human RIG-I polymorphisms identifies two variants with an opposite impact on the antiviral immune response. PLoS One. 2009 Oct 27;4(10):e7582.

Peter M*, Kubarenko A*, Weber AN $, Dalpke A $. Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation. J Immunol. 2009 Jun 15;182(12):7690-7. 
*equal contribution, $shared senior authorship.

2008

Gangloff M, Murali A, Xiong J, Arnot CJ, Weber AN, Sandercock AM, Robinson CV, Sarisky R, Holzenburg A, Kao C, Gay. Structural insight into the mechanism of activation of the Toll receptor by the dimeric ligand Spätzle. NJ. J Biol Chem. 2008, 283(21):14629-35.

2007

Kubarenko A, Frank M, Weber AN. Structure Function Relationships of Toll-Like Receptor Domains through Homology Modelling and Molecular Dynamics. Biochem Soc Trans 2007, 35: 1515-8.

Tanji T, Hu X, Weber AN, Ip YT. Toll and IMD pathways synergistically activate an innate immune response in Drosophila melanogaster. Mol Cell Biol. 2007, 27:4578-88..

Weber AN, Moncrieffe MC, Gangloff M, Imler JL, Gay NJ. Role of the Spätzle Pro-domain in the Generation of an Active Toll Receptor Ligand. J Biol Chem., 2007, 282(18):13522-13531.

2006

Wang L, Weber AN, Atilano ML, Filipe SR, Gay NJ, Ligoxygakis P. Sensing of Gram-positive bacteria in Drosophila: GNBP1 is needed to process and present peptidoglycan to PGRP-SA. EMBO J, 2006; 25(20):5005-14.

2005

Weber AN, Moncrieffe MC, Gangloff M, Imler JL, Gay NJ. Ligand-receptor and receptor-receptor interactions act in concert to activate signaling in the Drosophila Toll pathway. J Biol Chem. 2005;280(24):22793-9.

2004

Weber AN, Morse MA, Gay NJ. Four N-linked glycosylation sites in human Toll-like receptor 2 cooperate to direct efficient biosynthesis and secretion. Journal of Biological Chemistry, 2004; 279: 34589 - 34594.

2003

Weber AN, Tauszig-Delamasure S, Hoffmann JA, Lelievre E, Gascan H, Ray KP, Morse MA, Imler JL, Gay NJ. Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signalling. Nature Immunology 2003 4(8):794-800.

schliessen

Reviews

Gasteiger G, D’Osualdo A, Schubert D, Weber AN, Bruscia E, Hornung V, Hartl D. Cellular innate immunity: new players – old questions. J Innate Immunity 2017; in press.

Mack I, Hector A, Ballbach M, Kohlhäufl J, Fuchs KJ, Weber A, Mall MA, Hartl D. The role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases. Mol Cell Pediatr. 2015 Dec;2(1):3. doi: 10.1186/s40348-015-0014-6.

Krüger P. Saffarzadeh M. Weber AN. Rieber N. Radsak M. von Bernuth H Roos D. Skokowa J. Hartl D. Neutrophils: between host defence. immune modulation and tissue injury. PLoS Pathog. 2015 Mar 12;11(3):e1004651.

Weber AN. Försti A. Toll-like receptor genetic variants and colorectal cancer. OncoImmunology 2014 Jan 1;3(1):e27763.

Gay NJ. Gangloff M. Weber AN. Toll-like receptors as molecular switches. Nature Reviews Immunology. 2006; 6:693-8.

Gangloff M. Weber AN. Gay NJ. Conserved mechanisms of signal transduction by Toll and Toll-like receptors. J Endotoxin Res. 2005. 11:294-8.

Gay NJ. Weber AN. Gangloff M. Activation of insect and vertebrate toll signaling: from endogenous cytokine ligand to direct recognition of pathogen patterns. Adv Exp Med Biol. 2005. 560:19-27.

Gangloff M. Weber AN. Gibbard RJ. Gay NJ. Evolutionary relationships but functional differences between the Drosophila and human Toll-like receptor families. Biochem Soc Trans. 2003. 31:659-63.

schliessen